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Head : Pr Peter Kamenicky, MD, PhD

Members: September 1st 2022

Permanent researchers ans clinicians:

Peter Kamenicky, Professor, PUPH, Paris-Saclay University
Philippe Chanson, Professor, PUPH, Paris-Saclay University
Agnès Linglart, Professor, PUPH, Paris-Saclay University

Eric Baudin, Clinician, PH, Gustave Roussy Institute
Sylvie Salenave, PH, Bicetre Hospital

Engineers – Technicians:

Nathalie Ladurelle, Research Engineer, IR2, Inserm
Shengyue Deng, Engineer, IE, Inserm (ANR grant)

Students:

Fanny Chasseloup, PhD student, Paris-Saclay University, Poste d’Accueil Inserm Fellowship
Anne-Sophie Lambert,PhD student, Paris-Saclay University, PH, Bicetre Hospital

Etienne Lefevre, Master 2 student, Paris-Saclay University


Themes:

Ectopic expression of the Glucose-dependent Insulinotropic Polypeptide Receptor (GIPR) receptor in endocrine tumors:
  • Implication of GIPR in the tumorigenesis and secretory activity of somatotropic pituitary adenomas responsible for acromegaly
  • Research of the molecular mechanisms leading to the ectopic expression of GIPR in pituitary tumors and in adrenal lesions
 
Invasive behavior of pituitary tumors:
  • Analysis of the molecular actors involved in the invasion of the cavernous sinus by pituitary tumors using a pan-genomic approach
  • Identification of therapeutic targets to inhibit the invasive behavior of pituitary tumors

These projects are funded by the ANR JCJC Intégral and benefit from the clinical expertise and patient cohorts of the Department of Endocrinology and Reproductive Diseases of Bicêtre Hospital.

 

5 main publications:

Loss of KDM1A in GIP-dependent primary bilateral macronodular adrenal hyperplasia with Cushing’s syndrome: a multicentre, retrospective, cohort study
Chasseloup F, Bourdeau I, Tabarin A, Regazzo D, Dumontet C, Ladurelle N, Tosca L, Amazit L, Proust A, Scharfmann R, Mignot T, Fiore F, Tsagarakis S, Vassiliadi D, Maiter D, Young J, Lecoq AL, Deméocq V, Salenave S, Lefebvre H, Cloix L, Emy P, Dessailloud R, Vezzosi D, Scaroni C, Barbot M, de Herder W, Pattou F, Tétreault M, Corbeil G, Dupeux M, Lambert B, Tachdjian G, Guiochon-Mantel A, Beau I, Chanson P, Viengchareun S, Lacroix A, Bouligand J, Kamenický P.
Lancet Diabetes Endocrinol. 2021 Dec;9(12):813-824.

Hypermethylator Phenotype and Ectopic GIP Receptor in GNAS Mutation-Negative Somatotropinomas.
Hage M, Chaligné R, Viengchareun S, Villa C, Salenave S, Bouligand J, Letouzé E, Tosca L, Rouquette A, Tachdjian G, Parker F, Lombès M, Lacroix A, Gaillard S, Chanson P, Kamenický P.
J Clin Endocrinol Metab. 2019 May 1;104(5):1777-1787.

Genomic Alterations and Complex Subclonal Architecture in Sporadic GH-Secreting Pituitary Adenomas.
Hage M, Viengchareun S, Brunet E, Villa C, Pineau D, Bouligand J, Teglas JP, Adam C, Parker F, Lombès M, Tachdjian G, Gaillard S, Chanson P, Tosca L, Kamenický P.
J Clin Endocrinol Metab. 2018 May 1;103(5):1929-1939.

Adrenal GIPR expression and chromosome 19q13 microduplications in GIP-dependent Cushing’s syndrome.
Lecoq AL, Stratakis CA, Viengchareun S, Chaligné R, Tosca L, Deméocq V, Hage M, Berthon A, Faucz FR, Hanna P, Boyer HG, Servant N, Salenave S, Tachdjian G, Adam C, Benhamo V, Clauser E, Guiochon-Mantel A, Young J, Lombès M, Bourdeau I, Maiter D, Tabarin A, Bertherat J, Lefebvre H, de Herder W, Louiset E, Lacroix A, Chanson P, Bouligand J, Kamenický P.
JCI Insight. 2017 Sep 21;2(18).

AIP mutations impair AhR signaling in pituitary adenoma patients fibroblasts and in GH3 cells.
Lecoq AL, Viengchareun S, Hage M, Bouligand J, Young J, Boutron A, Zizzari P, Lombès M, Chanson P, Kamenický P.
Endocr Relat Cancer. 2016 May;23(5):433-43.