Head : Say Viengchareun, PhD, HDR
Members: July 1st 2024
Permanent researchers and clinicians:
Say Viengchareun, Research Engineer, IRHC, Inserm
Pascal Boileau, Professor-Clinician, PUPH,Versailles-Saint Quentin en Yvelynes University
Laetitia Martinerie, Professor-Clinician, PUPH, Paris University
Eric Pussard, Associate Professor, MCU-PH, Paris-Saclay University
Students:
Margaux Laulhé, PhD student, Paris-Saclay University, ITMO Cancer Fellowship
Imene Hani, PhD student, Paris-Saclay University, MESRI Fellowship
Thèmes
Mineralocorticoid and glucocorticoid signaling:
- Mechanisms of regulation of the expression of the mineralocorticoid (MR) and glucocorticoid (GR) receptor
- Post-transcriptional control of mineralocorticoid receptor expression by RNA binding proteins and microRNA
- Identification of new MR and GR variants
- Interaction of MR and GR (heterodimerization) and with their transcriptional co-regulators: activation mechanism, dynamics, specificity
Pathophysiology of biosynthesis and corticosteroid signaling in newborns:
- Water and sodium wastings in premature and term infants
- Respiratory distress in preterm infants
- Identification of new modulators of the biosynthesis of corticosteroid hormones
- Analysis of plasma and urinary steroids by mass spectrometry (LC-MS/MS)
- Implementation of translational and clinical studies (PREMALDO and MINIPREM clinical trials)
- Congenital adrenal hyperplasia
These projects have the financial support of Inserm and University and of national (ANR) and European (IFCAH) funding agencies. They also benefit from the clinical expertise and patient cohorts of the Pediatric Endocrinology and Diabetology Service of the Robert Debré Hospital and of the Poissy Saint Germain hospital.
5 main publications:
A novel mutation in the NR3C1 gene associated with reversible glucocorticoid resistance.
Laulhé M, Kuhn E, Bouligand J, Amazit L, Perrot J, Lebigot E, Kamenickỷ P, Lombès M, Fagart J, Viengchareun S, Martinerie L.
Eur J Endocrinol. 2024 Mar 30;190(4):284-295.
The mineralocorticoid receptor modulates timing and location of genomic binding by glucocorticoid receptor in response to synthetic glucocorticoids in keratinocytes.
Carceller-Zazo E, Sevilla LM, Pons-Alonso O, Chiner-Oms Á, Amazit L, An Vu T, Vitellius G, Viengchareun S, Comas I, Jaszczyszyn Y, Abella M, Alegre-Martí A, Estébanez-Perpiñá E, Lombès M, Pérez P.
FASEB J. 2023 Jan;37(1):e22709.
Mineralocorticoid Receptor Antagonism by Finerenone Attenuates Established Pulmonary Hypertension in Rats.
Tu L, Thuillet R, Perrot J, Ottaviani M, Ponsardin E, Kolkhof P, Humbert M, Viengchareun S, Lombès M, Guignabert C.
Hypertension. 2022 Oct;79(10):2262-2273.
MiR-324-5p and miR-30c-2-3p Alter Renal Mineralocorticoid Receptor Signaling under Hypertonicity.
Vu TA, Lema I, Hani I, Cheval L, Atger-Lallier L, Souvannarath V, Perrot J, Souvanheuane M, Marie Y, Fabrega S, Blanchard A, Bouligand J, Kamenickỷ P, Crambert G, Martinerie L, Lombès M, Viengchareun S.
Cells. 2022 Apr 19;11(9):1377.
Preterm birth is assocaiated with epigenetic programming of transgenerational hypertension in mice.
Dumeige L, Nehlich M, Viengchareun S, Perrot J, Pussard E, Lombès M, Martinerie L.
Exp Mol Med. 2020 Jan;52(1):152-165.