Presentation of the Lab

Peter Kamenický, MD, PhD, is a professor of endocrinology at the French reference center for rare pituitary diseases, and for rare diseases of calcium and phosphate metabolism, at the Bicêtre Hospital and Paris-Saclay University, France. He leads the research laboratory UMR-S 1185 “Endocrine physiology and pathophysiology” at the Medical Faculty of Paris-Saclay University.
He is currently the clinical lead of the calcium & bone focus area of the European Society of Endocrinology.

Pr Peter Kamenickỷ

He received his medical degree from Komenský University in Bratislava, Slovakia, and earned his PhD in molecular endocrinology in 2008 at Paris-Sud University, France. His clinical expertise is mainly in the field of pituitary and adrenal diseases including acromegaly and Cushing’s syndrome, and around disorders of calcium and phosphate metabolism such as hypoparathyroidism and X-linked hypophosphatemia. His research focuses on (1) the genetics bases (AIP, KDM1A) and the molecular pathogenesis (ectopic GIP receptor expression) of acromegaly and bilateral adrenal hyperplasia, (2) the consequences of hormone’s (growth hormone, cortisol, parathyroid hormone) action in their target tissues including the kidney, heart, and bone, (3) the limitations and improvement of current therapies. His basic research also investigates the role histone demethylase KDM1A in the epigenetic control of hormone receptor expression programs in endocrine organogenesis and disease.
Three major interdependent and directly interactive themes are developed in parallel:

Theme 1 "Endocrine tumorigenesis", coordinated by Pr Peter Kamenickỷ, addresses two unresolved and clinically relevant questions concerning 1) the pathophysiology of somatotrophic adenomas without mutations responsible for the GNAS gene and 2) the molecular mechanisms of their invasive behavior.

Theme 2 "Gonadal physiopathology", coordinated by Dr Isabelle Beau, studies endocrine diseases which affect the hypothalamic-pituitary-gonadal function, which are responsible for abnormalities in puberty and fertility in humans. The objectives pursued in this theme will be to discover new factors of neuroendocrine control of gonadal diseases.

Theme 3 "Corticosteroid signaling pathophysiology of water and salt homeostasis", coordinated by Dr Say Viengchareun, will focus on the study of the regulation of corticosteroid signaling pathways during the perinatal period: from their biosynthesis to activation of their receptors (mineralocorticoid and glucocorticoid receptors). This translational program will aim in particular to explore the alterations in the salt and water balance associated with defects in corticosteroid synthesis and/or mineralocorticoid signaling in two pathological situations: loss of salt in very premature infants and congenital adrenal hyperplasia.