Head: Isabelle Beau, PhD, HDR
Members: July 1st 2024
Permanent researchers and clinicians:
Isabelle Beau, Assistant Professor, CRHC, Inserm
Jacques Young, Professor, PUPH, Paris-Saclay University
Anne Guiochon-Mantel, Professor, PUPH, Paris-Saclay University
Jérôme Bouligand, Professor, PUPH, Paris-Saclay University
Séverine Trabado, Associate-Professor, MCU-PH, Paris-Saclay University
Claire Bouvattier, Associate-Professor, MCU-PH, Paris-Saclay University
Charlotte Sonigo, Associate-Professor, MCU-PH, Paris-Saclay University
Luigi Maione, Associate-Professor, MCU-PH, Paris-Saclay University
Engineers – Technicians:
Françoise Magnin, Technician, TCE, Inserm
Students:
Victoire Perraud, Master 2 student, Paris-Saclay University
Morgane Carré-Lecoindre, Master 2 student, Paris-Saclay University
Nadia Zaegel, Master 2 student, Paris-Saclay University
Caroline Berthot, Master 2 student, Paris-Saclay University
Themes:
Molecular explorations of gonadal pathology:
- Analysis of the actors of primary ovarian insufficiency
- Characterization of molecular interactions between partners in folliculogenesis
- Fertility preservation
Congenital hypogonadotropic hypogonadism (CHH):
- Pan-genomic approach for the identification of new genes involved in the pathology
- Functional characterization of mutations
5 main publications:
Anti‐Müllerian hormone induces autophagy to preserve the primordial follicle pool in mice.
Tatiana Lecot-Connan, Yasmine Boumerdassi, Françoise Magnin, Nadine Binart, Peter Kamenický, Charlotte Sonigo, Isabelle Beau
FASEB J 2024; 38(5) e23506
BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency.
Renault L, Patiño LC, Magnin F, Delemer B, Young J, Laissue P, Binart N, Beau I.
J Clin Endocrinol Metab. 2020 Apr 1;105(4).
AMH prevents primordial ovarian follicle loss and fertility alteration in cyclophosphamide-treated mice.
Sonigo C, Beau I, Grynberg M, Binart N.
FASEB J. 2019 Jan;33(1):1278-1287.
ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure.
Delcour C, Amazit L, Patino LC, Magnin F, Fagart J, Delemer B, Young J, Laissue P, Binart N, Beau I.
Genet Med. 2019 Apr;21(4):930-938.
Clinical Management of Congenital Hypogonadotropic Hypogonadism.
Young J, Xu C, Papadakis GE, Acierno JS, Maione L, Hietamäki J, Raivio T, Pitteloud N.
Endocr Rev. 2019 Apr 1;40(2):669-710.