Theme 2

 bande theme 2

Isabelle Beau







Head: Isabelle Beau, PhD, HDR

Members: September 1st 2022

Permanent researchers and clinicians:

Isabelle Beau, Assistant Professor, CRHC, Inserm
Jacques Young, Professor, PUPH, Paris-Saclay University
Anne Guiochon-Mantel, Professor, PUPH, Paris-Saclay University

Jérôme Bouligand, Associate-Professor, MCU-PH, Paris-Saclay University
Séverine Trabado, Associate-Professor, MCU-PH, Paris-Saclay University
Claire Bouvattier, Associate-Professor, MCU-PH, Paris-Saclay University
Charlotte Sonigo, Associate-Professor, MCU-PH, Paris-Saclay University
Luigi Maione, Associate-Professor, PHU, Paris-Saclay University, Paris Hospital

Engineers – Technicians:

Françoise Magnin, Technician, TCE, Inserm


Kenneth Chappell, PhD student, Paris-Saclay University (co-Direction)
Tatiana Lecot-Connan, Master 2, Paris-Saclay University
Laura Takour-Mardivirin, Master 2, Paris-Saclay University
Le Saëc Marion, Master 1,
Paris-Saclay University


Molecular explorations of gonadal pathology:

  • Analysis of the actors of primary ovarian insufficiency
  • Characterization of molecular interactions between partners in folliculogenesis
  • Fertility preservation

Congenital hypogonadotropic hypogonadism (CHH):

  • Pan-genomic approach for the identification of new genes involved in the pathology
  • Functional characterization of mutations

5 main publications:

BMPR1A and BMPR1B Missense Mutations Cause Primary Ovarian Insufficiency.
Renault L, Patiño LC, Magnin F, Delemer B, Young J, Laissue P, Binart N, Beau I.
J Clin Endocrinol Metab. 2020 Apr 1;105(4).

AMH prevents primordial ovarian follicle loss and fertility alteration in cyclophosphamide-treated mice.
Sonigo C, Beau I, Grynberg M, Binart N.
FASEB J. 2019 Jan;33(1):1278-1287.

Prolactin – a pleiotropic factor in health and disease.
Bernard V, Young J, Binart N.
Nat Rev Endocrinol. 2019 Jun;15(6):356-365.

ATG7 and ATG9A loss-of-function variants trigger autophagy impairment and ovarian failure.
Delcour C, Amazit L, Patino LC, Magnin F, Fagart J, Delemer B, Young J, Laissue P, Binart N, Beau I.
Genet Med. 2019 Apr;21(4):930-938.

Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration.
Sonigo C, Bouilly J, Carré N, Tolle V, Caraty A, Tello J, Simony-Conesa FJ, Millar R, Young J, Binart N.
J Clin Invest. 2012 Oct;122(10):3791-5.